SAMPLE PACK: Delta-9-THC Gummies – Mixed Berry

Simple Leaf’s full spectrum organic hemp extract contains CBD and a wide range of cannabinoids, including THC.  All of our lab tests verify the THC levels are always under the 0.3% legal limit.

This usually amounts to 1mg of THC per softgel.  This is not usually enough THC to make an adult the slightest bit high, but if you are subject to drug testing, then a THC-free product (like our capsule CBD products) may be a better choice.

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Terpenes are naturally occurring chemical compounds found in plants and some animals. They’re responsible for the aromas, flavors, and even colors associated with various types of vegetation. In terms of cannabis, terpenes are what make certain strains smell or taste different from others.

They can also be processed into produce products, like cleaning solvents, pesticides, and dyes. Some even have therapeutic properties.

While nearly all plants contain terpenes, some of the more common sources people encounter them include:

• cannabis
• aromatic herbs, like sage and thyme
• citrus fruits

There are about 400 known terpenes in cannabis, but experts have only linked a handful of them to specific effects.

Here are some common terpenes and their potential effects:

Beta-caryophyllene. A major ingredient in cloves, rosemary, and hops, beta-caryophyllene could be beneficial for managing symptoms of anxiety and depression.

Beta-pinene. If you’ve strolled through a coniferous forest, you know the smell of beta-pinene, which could also have potentially both anti-depressant and anti-cancer properties.

Humulene. This terpene is found in ginseng, which has long been used in folk medicine for energizing effects.

Limonene. One of the most commonly found terpenes, limonene has distinct citrus notes and may potentially have anti-cancer properties. In mice, it’s been shown to have anti-anxiety properties.

Linalool. Lovers of lavender as aromatherapy may want to seek out cannabis with linalool, which may help alleviate stress.

Myrcene. Found in mangoes, myrcene has antifungal and antibacterial properties and could also have sedating effects.

Keep in mind that much of the research around terpenes is still in early stages. More high quality studies in humans are needed to fully understand the health impacts of different terpene profiles.

Beta-caryophyllene is unique among terpenes in that it acts as a cannabinoid and targets the CB2 receptors in the body’s endocannabinoid system. In many ways, beta-caryophyllene is an important reminder that terpenes and cannabinoids are not separate and that the two work in conjunction with one another.

Terpenes influence how cannabinoids behave and can modify how much THC crosses the blood-brain barrier (BBB). Terpenes can also regulate the production and decomposition of neurotransmitters like dopamine and serotonin.

Terpenes like beta-caryophyllene also affect flavor and combine with flavonoids and cannabinoids to produce unique therapeutic effects (the entourage effect). While different terpenes and cannabinoids have other effects at different dosages in various combinations, it is essential to remember that they are all interlinked.

Beta-caryophyllene is a potent anti-inflammatory and provides pain relief, potentially useful for inflammation and neuropathic pain. Beta-caryophyllene also has the potential to act as an anti-anxiety medication. 

Although beta-caryophyllene has physiological effects, it does not bind to CB1 receptors and has no psychoactive effects. And for all its benefits, studies have found little-to-no adverse side effects in beta-caryophyllene.

The therapeutic benefits of Cis-Nerolidol are widespread and well-documented, including the inhibition of tumors and fungus as well as possessing antioxidant and antibacterial qualities. Other suggested medicinal use cases of Cis-Nerolidol include inducing drowsiness and soothing topical conditions.

Researchers are currently studying potential health benefits, including the nerolidol terpene’s different effects on different people. Researchers need to conduct clinical trials in order to develop a better understanding of nerolidol’s effects on humans.

Antifungal

One 2007 study published in the Biological & Pharmaceutical Bulletin analyzed the effectiveness of nerolidol against a skin fungus in guinea pigs. Researchers found that nerolidol seemed to act as an antifungal agent in a clinically effective manner on the guinea pigs.

Sedative

A 2013 study published in the journal Neurochemical Research revealed that nerolidol appeared to have a sedative and antioxidant effect on rodent test subjects. More research is needed to understand if nerolidol could function as a sleep aid for humans.

Antioxidant

One 2016 study published in the journal BMC Neuroscience showed that nerolidol had apparent antioxidant properties in rodents. Researchers found that nerolidol protected against oxidative stress and exhibited potential in treating neurological conditions, such as Parkinson’s disease.  

Anticancer

In 2017 Basic & Clinical Pharmacology & Toxicology published a study that demonstrated how cis-nerolidol arrested cell growth and induced cell death in human liver cancer. 

Antibacterial and antimicrobial

Nerolidol terpene effects may include the ability to make certain strains of bacteria more susceptible to antibiotics, as uncovered in a 2003 study published in the journal Antimicrobial Agents and Chemotherapy. Further, a 2007 animal study published in the Netherlands in the International Journal of Antimicrobial Agents discovered that the terpene could be a tool against malaria when used with other drugs.

Anti-anxiety

A 2016 study published in the Indian Journal of Pharmacology found that nerolidol seemed to have an anti-anxiety effect in mice. 

Skin lesions

A 2007 study published in the International Journal of Pharmaceutics found that nerolidol was a skin penetration enhancer of topical agents on animals, which could possibly benefit skin lesions. Further research is necessary to determine if nerolidol could exert an effect on human skin lesions.